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The role of WH2 domains in nuclear gene expression and actin nucleation

Finanzierung:
Deutsche Forschungsgemeinschaft (DFG) ;
Beside its prominent role in cytoplasmic F-actin formation, actin nucleation also affects processes within the cell nucleus, such as gene expression through SRF and its coactivator MAL/MRTF. However, the precise connection between the nucleation promoting factors (NPFs), nuclear actin and MAL/SRF is unclear. The aim of this proposal is to elucidate the role of WH2-domains and -NPFs in nuclear processes, i.e. MAL/SRF-mediated transcription and formation of nuclear actin polymers. We will analyse the WH2-MAL competition by biochemical experiments and in living cells by imaging. Using both candidate approaches and unbiased screening, we will attempt to identify the critical WH2-containing NPFs.

Schlagworte

Genregulation, Molekulare Medizin, Signaltransduktion, Zellbiologie

Kontakt

Prof. Dr. Guido Posern

Prof. Dr. Guido Posern

Martin-Luther-Universität Halle-Wittenberg

Medizinische Fakultät

Institut für Physiologische Chemie

Hollystr. 1

06114

Halle (Saale)

Tel.+49 345 5573805

Fax:+49 345 5573811

guido.posern(at)uk-halle.de

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