Dissecting the relevance of Hippo signaling in mediating ultra sound-activated stem cell activation in the healthy and diseased human liver

By using patient-derived and iPSC-derived in vitro models of hepatocytes and hepatic cancer, we investigate the potential of Hippo signaling pathway in controlling maintenance of stem cell features. The project also investigates ultra sound stimulation and its potential as intro operative applicable technology to intersect in the mentioned context.