Bedeutung von RAGE und Endoglin an der alveolo-kapillären Membran für die BPD-Entwicklung in Frühgeborenen durch Hypoxie-Hyperoxie

Our study aims at the establishment of a co-culture model mimicking the human fetal alveolo-capillary membrane that is suited to study the influence of oxygen and other factors, including alveolar RAGE and endothelial Endoglin, on BPD development. In this regard, we also aim at the RAGE-dependent analysis of Endoglin during BPD development caused by pathological oxygen concentrations in vitro and in vivo.