Understanding the crosstalk of metal ions on a cellular basis requires multidisciplinary and cooperative approaches that span the entire range from cell and molecular biology, biochemistry, inorganic chemistry, and structural biology to theory and spectroscopy. In the SPP it is planned to study novel enzyme mechanisms, innovative model complexes, and new biogenesis pathways in the (patho-)physiological context of metalloenzymes in living organisms. The following fundamental areas will be addressed:
- Assembly of FeS proteins as a starting point for versatile functionality
- Biosynthesis and crosstalk of complex metal cofactors by FeS proteins
- Catalysis and functions of complex FeS proteins for bio-applications
- Disease-relevant roles of FeS proteins in cellular metal homeostasis
The main aspects will lie on understanding the role of FeS clusters in H2-conversion, nitrogen-cycling and disease-related pathways in Bacteria, Archaea and Eukarya including mammals, plants and fungi. Further, the program aims at the development of future cellular systems for bioenergy production, fertilization and bio-applications. In order to adequately address these questions, novel, interdisciplinary concepts and approaches shall be combined with novel technological advancements.