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Publikationen
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Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation
Weiße, Jonas ; Rosemann, Julia ; Müller, Lisa ; Kappler, Matthias ; Eckert, Alexander W. ; Glaß, Markus ; Misiak, Danny ; Hüttelmaier, Stefan ; Ballhausen, Wolfgang G. ; Hatzfeld, Mechthild ; Hämmerle, Monika ; Gutschner, TonyMolecular cancer - London : Biomed Central, Bd. 20 (2021), Artikel 88
Regulation of gene expression is one of the most fascinating and most complex tasks of the cell. The research projects in our lab aim to unravel the molecular function and regulatory principles applied by non-coding RNAs (ncRNAs) and RNA-binding proteins (RBPs) in cancer cells. To achieve this goal, we will develop novel genome engineering and gene targeting strategies, which we combine with classical cell biology and biochemical approaches to dissect molecular pathways and interaction networks of these important regulators in the context of tumor biology. Ultimately, we want to identify vulnerabilities in human cancers that display an unbalanced expression of ncRNAs and RBPs leveraging unbiased genetic screening tools (e.g. CRISPR/Cas9). These efforts might reveal novel therapeutic targets and treatment options.
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