« Projekte
Sie verwenden einen sehr veralteten Browser und können Funktionen dieser Seite nur sehr eingeschränkt nutzen. Bitte aktualisieren Sie Ihren Browser. http://www.browser-update.org/de/update.html
Effects of hippocampal vascularization patterns on the neural resources of MTL neurocognitive circuits
Prof. Dr. habil. Stefanie Schreiber , Dr. rer. nat. Anne Maass, Dr. rer. nat. Esther Kühn
Deutsche Forschungsgemeinschaft (DFG) ;
Effects of hippocampal vascularization patterns on the neural resources of MTL neurocognitive circuits
Visualization of hippocampal supply. Representation of the hippocampal supply using a maximum intensity projection of the 7 T ToF-angiography in MeVisLab. The hippocampal mask obtained from the T1-weighted sequence was adopted as an anatomical reference. In case of mixed hippocampal supply (A and B) the anterior choroidal artery (AchA, in violet) participates to the vascularization with an uncal branch (highlighted in pink) together with the hippocampal arteries (in yellow) which arise from the posterior cerebral artery (PCA, in green) or its branches. In case of single hippocampal supply (C and D) no uncal branch can be detected. From: Valentina Perosa, Anastasia Priester, Gabriel Ziegler, Arturo Cardenas-Blanco, Laura Dobisch, Marco Spallazzi, Anne Assmann, Anne Maass, Oliver Speck, Jan Oltmer, Hans-Jochen Heinze, Stefanie Schreiber*, Emrah Düzel* (eq.), Hippocampal vascular reserve associated with cognitive performance and hippocampal volume, Brain, Volume 143, Issue 2, February 2020, Pages 622–634, https://doi.org/10.1093/brain/awz383
The hippocampus and adjacent entorhinal cortex (EC) form a neural circuit within the medial temporal lobe (MTL) that is crucial for episodic memory formation. Integrity of this circuit is massively affected by age-related degeneration, partly due to pathology (e.g. tau, microinfarcts), partly due to environmental factors. Interestingly, the pattern of hippocampal vascularization varies among individuals, that is, there are individuals with a single supply, and there are individuals with a double supply.
We recently found out that the individual vascularization profile interacts with verbal memory and global cognition: participants with a double supply had higher scores in the California Verbal Learning Test (CVLTII). What is not clear so far is which neuronal mechanisms underlie this effect. How does the individual vascularization profile affect cognitive aging? How does a double supply contribute to cognitive resource, and does it interact with training success?
These are the key questions addressed in this project within the CRC 1436. Here, we use the beneficial effect of a double hippocampal blood supply as model to understand the neuronal basis of cognitive resources in younger and older adults. By using ultra-high resolution functional and structural imaging at 7 Tesla together with advanced modeling techniques, we will investigate how the fine-grained hippocampal vascular supply affects age-related MTL pathology, MTL integrity, and MTL myeloarchitecture (neural resources), and how this mediates subregion-specific memory function (cognition). Finally, we will test how the effect of cognitive interventions on MTL function is modified by the hippocampal vascularization patterns.

Kooperationen im Projekt


Die Daten werden geladen ...

weitere Projekte

Die Daten werden geladen ...