Stellenwert der Präimplantationsbiopsie für die Allokation von Leichennieren

Es soll untersucht werden, inwieweit anhand des Biopsiebefundes entschieden werden kann, ob ein Organ zur Nierentransplantation akzeptiert werden kann oder nicht. Diese Frage betrifft sogenannte, nach klassischen Kriterien für die Organannahme eingestufte 'marginale' Organe.
Projektleiter: Christos Chatzikyrkou

Utilization and outcomes of deceased donor kidneys evaluated by preimplantation biopsy

We aim to evaluate the impact of individual histological lesions in preimplantation biopsies from donors with brain death on graft and recipient survival. For this purpose donor and recipient clinical data will be retrieved and each biopsy will be assessed for histopathological lesions which have been found to be of prognostic relevance. Our goal is to develop of composite histological score that helps the clinician to correctly decide about the suitability of the kidney for transplantation by avoiding to discard organs with otherwise good outcome and by diminishing the risk of transplanting kidneys with short projected survival.