The ubiquitin-proteasome-system in immune response to infection
The ubiquitin-proteasome system (UPS) is responsible for the maintenance of cellular protein homeostasis. As response to pathogenic challenges type I and type II interferons are released and in consequence the expression of various components of the UPS is altered. Based on our previous results that ubiquitinating enzymes E1, E2 and E3 are affected by interferon (Seifert et al., 2010), we will analyze the expression and function of enzymes involved in ubiquitylation during infection. In addition, our previous results pointed to a role of immunoproteasomes, a specific isoform of proteasomes containing the immunosubunits LMP2, LMP7 and MECL-1, for enhanced degradation of the inhibitor of NFkappaB, ikappaBalpha. The goal of our project is to determine alterations in enzymes involved in ubiquitylation and deubiquitylation of components of the NFkappaB signalling pathway. The data obtained from these experiments will be used as basis for the generation of combined mathematical and biological models of the UPS in infection.
Anschubfinanzierung des Forschungszentrums Dynamische Systeme: Biosystemtechnik
Immunantwort, NF-kappaB Aktivierung
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