Forschungsportal Sachsen-Anhalt
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Post-transcriptional regulation of the myocardin-related coactivators during muscle cell differentiation

Finanzierung:
Deutsche Forschungsgemeinschaft (DFG) ;
The development and differentiation of muscle cells is a tightly regulated process including several signaling pathways, transcription factors and post-transcriptional processes. The MRTF family of transcription factors are coactivators of Serum Response Factor (SRF) and control several muscle-specific genes, including skeletal muscle alpha-actin (acta1; SMA), smooth muscle alpha-actin (acta2; SkMA), myosin heavy chain and SM22. However, the regulation of MRTF expression itself and the details of the MRTF-dependent muscle differentiation are unknown.

Within this project we aim to investigate which miRNAs in muscle cells bind and suppress the mRNA of MRTF-A and how they modulate muscle cell differentiation and behavior. The miRNAs found will be analyzed by altering their expression level and monitoring the effects on MRTF-A expression and activity. We expect to gain new insights into muscle differentiation and how a miRNA-MRTF circuit is involved.

Schlagworte

Genregulation, Molekularbiologie, Signaltransduktion, Zellbiologie

Kontakt

Prof. Dr. Guido Posern

Prof. Dr. Guido Posern

Martin-Luther-Universität Halle-Wittenberg

Medizinische Fakultät

Institut für Physiologische Chemie

Hollystr. 1

06114

Halle (Saale)

Tel.+49 345 5573805

Fax:+49 345 5573811

guido.posern(at)uk-halle.de

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