Genexpressionsprofiling von murinen pankreatischen Fibroblasten zu verschiedenen Zeitpunkten der Karzinogenese

Pancreatic cancer is a very aggressive disease with limited therapeutic options and a bad prognosis. Pancreatic ductal adenocarcinoma (PDAC) is surrounded by a very dense stroma that has an important role and consists of multiple different cell types: among them are pancreatic stellate cells (PSC/activated myofibroblasts) that produce parts of the extracellular matrix and influence cancer cells and vice versa. In this study, we are interested in how these fibroblasts change their expression profile during carcinogenesis. A genetically engineered mouse model of pancreatic cancer will be used for this project.