REJUVENATE: Rerouting towards REsilience to JUVENile stress-induced psychopAThologiEs in adulthood: Spotlight on behavioural profiling and lifestyle interventions (Funded by ERA-NET NEURON – 2023 Call) - € ~274,000 (€ 1,081,000 total funding) (DFG, Projektnummer: 542950222)

Childhood adversities have long-lasting consequences in terms of mental health and well-being, and, exposure to childhood adversities (Juvenile stress [JS]) significantly increases vulnerability to mood and
anxiety disorders later in life. Yet, not all show an increased risk of adulthood psychopathology. Some individuals develop resilience, helping them to better cope with later life challenges. Our primary
objectives are (1) To elucidate mechanisms relating JS to vulnerability and resilience to stressful challenges in adulthood, and (2) To test the therapeutic/preventive potential of translational life-style interventions on the negative impact of JS later in life (i.e., boosting resilience). Our secondary objective is to systematically address sex-related differences in sensitivity, in related mechanisms underlying stress vulnerability or resilience, and in the effectiveness of life-style interventions for enhancing mental health resilience.