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Profil • Service

Vita

CURRENT POSITION

from 01/2020

Researcher, Group Leader, Research Group “Synapto-Oscillopathies”
Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany

06/2022-09/2022

Parental Leave (Elternzeit)



EDUCATION / PREVIOUS POSITIONS

10/2014-12/2019

Postdoctoral Research Associate, Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany, Advisor: Prof. Dr. Oliver Stork

04/2009-09/2014

PhD Student and Research Associate, Humboldt University and Free University of Berlin, Charité Medical Faculty, Germany
PhD Thesis: “Role of hippocampal network activities in stress- and fear-related processes”, Dr. rer nat. (04.09.2015) Grade: summa cum laude, Advisor: Prof. Dr. Uwe Heinemann

11/2008-03/2009

Guest Student, Department of Psychology, University of Otago, Dunedin, New     Zealand, Prof. Dr. David K. Bilkey; Training on in vivo tetrode recordings and data analysis

10/2008

Guest Student, Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Tröndheim, Norway, Prof. Edvard Moser and Prof. May-Britt Moser; Training on in vivo tetrode recordings and data analysis

09/2006-06/2008

Master Course International Graduate Program-Medical Neurosciences, Humboldt University, Charité Medical Faculty, Berlin-Germany
Master Thesis: “Effects of Nicotine on Memory-Related Hippocampal Network Oscillations in Vitro”, MSc in Medical Neurosciences (16.05.2008) Grade: 1.5 (85%), Advisor: Prof. Dr. Uwe Heinemann

09/2002-06/2006

Undergraduate studies of Molecular Biology and Genetics, Istanbul Technical University, Istanbul-Turkey - BSc (21.06.2006) GPA: 3.33 out of 4.00 possible



RESEARCH FOCUS
I have been studying cellular and circuit-level changes in animal models of fear and anxiety via combining different approaches including electrophysiology, behaviour and pharmacogenetics (DREADDs). My current research focuses on identification of physiological and pathological alterations in the hippocampal activity patterns and their relation to modulation of hippocampal engrams in animal models of neuropsychiatric disorders. I am also interested in the impact of environmental factors and their interactions with immune system in mediation of affective behaviour.

GRANTS

01/2020-12/2022

Principal Investigator - NeuroNetwork: “A Neuronetwork for functional analysis of the engram connectome"; Subproject: "Bottom-up modulation of hippocampal engrams via sustained amygdalar activity" (Funded by the federal state of Saxony-Anhalt and the „European Regional Development Fund“ (ERDF 2014-2020); Center for Behavioral Brain Sciences, grant ID: ZS/2016/04/78113) - € 155,710 (€ 465,000 total funding)

06/2018-
01/2020

Postdoctoral Fellowship CBBS ScienceCampus -"Elucidating the role of ventral hippocampal network oscillations in fear memory persistence" (Funded by the Leibniz Association, grant ID: SAS-2015-LIN-LWC) - € 80,000



AWARDS

10/2022

CBBS Best Paper Award 2021: “Çaliskan G, et al., Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus. Brain Behav Immun. 2021 Oct 18;99:203-217

11/2021

Selected to attend the Cajal course on Optogenetics, chemogenetics and biosensors for cellular and circuit neuroscience Bordeaux School of Neuroscience in Bordeaux, France, on 22 November - 10 December 2021

07/2021

Travel Award, The 44th Annual Meeting of the Japan Neuroscience Society 2021 in Kobe Convention Center, July 28-31, 2021

04/2017

Travel Award, IBRO-PERC, The Brain Prize and FENS Stipend, the Spring Brain Conference 2017, Learning, Memory and Synaptic Plasticity, Rungstedgaard, Denmark

11/2016

Travel Award, German Neuroscience Society-Leopoldina, „Brains in vivo and in silico: from Synapses and Circuits to Brain-Inspired Technologies" in Jerusalem, Israel

07/2016

FENS /IBRO Travel Award, Copenhagen, Denmark

10/2015

Travel Award, FENS Featured Regional Meeting, Thessaloniki, Greece

04/2009-06/2011

Doctoral PhD stipend, Graduate School Learning and Memory (GRK 1123), Humboldt University and Free University of Berlin, Charité Medical Faculty, Germany

07/2007

Travel Award, Onassis Foundation Science Lecture Series, Lectures in Biology devoted to "Channels and Channelopathies", Crete, Greece



TEACHING AND MENTORING
Graduate Neuroscience Courses:
Three Lectures, two practical courses, a writing course and a seminar series in MSc Integrative Neuroscience Program:

from 04/2022

Lecture on "Neuromodulation and Neuropeptides"

from 11/2021

Co-supervision of a writing course for master thesis project proposal - “Neural Signalling”

from 11/2021

Lecture on "Dendritic Integration"

from 11/2018

Lecture on "Synaptic plasticity"

from 10/2016

Co-supervision of a practical course on Genetic models

from 04/2015

Lecture on "Cellular mechanisms of network oscillations in the brain"

from 06/2015

Seminar Series

from 01/2015

Lead supervision of a course on recording and analysis of electrophysiological data


Mentoring:
Currently direct supervision of 2 MSc, 1 PhD student and co-supervision of 2 PhD Students.
Supervision of several lab rotations (~1 month) and long-term internships (4-to-9 months) of BSc and MSc students (13 in total) and 2 MSc Theses.

ORGANIZATION OF CONFERENCES/SYMPOSIA

03/2021

ISYNC: International SynAGE conference on healthy ageing (Organization of scientific sessions)

09/2019

MCB-Brain Plasticity International Conference (Organization committee- Postdocs in Magdeburg Science Community, funded by CBBS)

11/2010

Berlin Brain Days (Invitation of Nobel Laureate Prof. Edvard Moser)

04/2009

Berlin Brain Days (Invitation of Prof. Gábor Támás)



INVITED SEMINARS AND TALKS

12/2022

Blitz Talk, SynAGE Retreat, Wanzleben, Germany

10/2022

“CBBS Paper of the year 2021", CBBS General Assembly, Magdeburg, Germany

09/2022

Invited Talk, Multi lab retreat/symposium CoSMOs 2022, Prague, Czech Republic

05/2022

5th Conference on the Functional Architecture of Memory - Blitz Talk, Magdeburg, Germany

05/2022

"GC-I³ Paper of the year 2021" Symposium, Magdeburg, Germany

02/2022

Invited CBBS – Ring Lecture, Magdeburg, Germany

03/2021

Invited Seminar Series – Mikulovic / Remy Lab - Leibniz Institute for Neurobiology, Magdeburg, Germany

08/2020

Invited Lecture Series - RTG 2413 - SynAGE

09/2019

Session chair and talk, MCB-Brain Plasticity International Conference, Magdeburg, Germany

03/2019

Replacement talk, Proteins and Circuits in Memory, Copenhagen, Denmark

12/2018

Invited Seminar, Friedrich-Alexander-University of Erlangen-Nuremberg

10/2018

Invited Seminar, Junior Researcher Journal Club, Magdeburg, Germany

05/2018

Invited Lecture Series – ABINEP Graduate School

03/2017

37th European Winter Conference on Brain Research, Les Arcs 1800, France



MEMBERSHIPS IN SCIENTIFIC SOCIETIES

from 01/2016

Federation of European Neurosciences (FENS)

from 01/2016

German Neuroscience Society



REVIEWING/EDITING ACTIVITIES

from 2023
from 2022

from 2023
from 2023

Grant Reviewer, Italian Ministry of University and Research
Grant Reviewer, The German-Israeli Foundation for Scientific Research and Development (GIF)
Reviewer, Cell Reports
Reviewer, Journal of Neurochemistry

from 2022

Reviewer, Translational Neurodegeneration

from 2022

Reviewer, Molecular Neurobiology

from 2022

Reviewer, Neuropsychopharmacology

from 2022

Reviewer, Journal of Neuroimmunology

from 2021

Reviewer, Hippocampus

from 2021

Reviewer, Neural Regeneration Research

from 2021

Guest Associate Editor, Frontiers in Behavioural Neuroscience

from 2021

Reviewer, Bioengineered-TAND

from 2021

Reviewer, Cells-MDPI

from 2020

Reviewer, Scientific Reports

from 2020

Reviewer, Brain Research Bulletin

from 2020

Reviewer, Psychoneuroendocrinology

from 2020

Guest Associate Editor, Frontiers in Neural Circuits - Research Topic

from 2020

Reviewer, International Journal of Molecular Sciences

from 2020

Reviewer, Molecular and Cellular Neuroscience

from 2019

Reviewer, Cerebral Cortex

from 2019

Reviewer, Neuropharmacology

from 2018

Reviewer, Frontiers in Molecular Neuroscience

from 2018

Reviewer, Neurobiology of Learning and Memory

from 2015

Reviewer, Stress- The International Journal on the Biology of Stress



LANGUAGES

Turkish

Native proficiency

English

Full professional proficiency

German

Limited professional proficiency (~B2)



RELEVANT QUALIFICATIONS

From 2009

FELASA certificate, the Federation of European Laboratory Animal Science Associations

From 2016

Security officer at the Institute of Biology, Otto-von-Guericke University Magdeburg

From 2017

Deputy Head of two Animal experimentation projects (Tierversuchsvorhabens nach § 8 Abs. 1 des Tierschutzgesetzes)

From 2020

Member of an appointment committee for Professorship at the Institute of Biology, Otto-von-Guericke University Magdeburg

From 2021

First Aid officer at the Institute of Biology, Otto-von-Guericke University Magdeburg

From 2021

Project Leader Qualification (Projektleiterkurs nach § 28 Abs. 2 der Gentechnik-Sicherheitsverordnung)



PUBLICATIONS
Number of Papers in peer-reviewed journals: 28 (15 first or shared first authorships; 1 last/senior authorship)
(Citations=557, h-index=14, Based on Scopus database; Date: 12.08.2023, full publication list available via: https://www.scopus.com/authid/detail.uri?authorId=36937488100)

Preprints:
32: Blondiaux A, Jia S, Annamneedi A, Çalışkan G, Schulze J, Montenegro-Venegas C, Wykes RC, Fejtova A, Walker MC, Stork O, Gundelfinger ED, Dityatev A, Seidenbecher CI. (2023) Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy. bioRxiv 2023.04.19.537468. doi: 10.1101/2023.04.19.537468
 
31: Raza SA, Klinger K, del Ángel M, Demiray YE, Çaliskan G, Kreutz MR, Stork O (2022) Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization. bioRxiv 2022.04.26.489543; doi: 10.1101/2022.04.26.489543
 
30: Pollali E, Hollnagel J-O, Çaliskan G# (2022) Hippocampal gamma-band oscillopathy in a mouse model of Fragile X Syndrome. bioRxiv 2021.04.24.441239; doi: https://doi.org/10.1101/2021.04.24.441239. # Senior/Corresponding Author
 
Editorials:
29: Çaliskan G#, Mikulovic S# and Girardeau G# (2022) Editorial: Functional Aspects of Mesoscopic Brain Oscillations: Insights From in vivo and in vitro Studies. Front. Neural Circuits 16:960157. doi: 10.3389/fncir.2022.96015. #Corresponding Author

Published papers in peer-reviewed journals:

28: Çalışkan G, Demiray YE, Stork O. Comparison of three common inbred mouse strains reveals substantial differences in hippocampal GABAergic interneuron populations and in vitro network oscillations. Eur J Neurosci. 2023 Aug 7. doi: 10.1111/ejn.16112. Epub ahead of print. PMID: 37550182. # Corresponding Author

27: Ulrich M, Pollali E, Çalışkan G, Stork O, Albrecht A. Sex differences in anxiety and threat avoidance in GAD65 knock-out mice. Neurobiol Dis. 2023 Jul;183:106165. doi: 10.1016/j.nbd.2023.106165. Epub 2023 May 23. PMID: 37230180.

26: Albrecht A, Müller I, Weiglein A, Pollali E, Çaliskan G, Stork O. Choosing memory retrieval strategies: A critical role for inhibition in the dentate gyrus. Neurobiol Stress. 2022 Jul 31;20:100474. doi: 10.1016/j.ynstr.2022.100474. PMID: 35958670; PMCID: PMC9357949.
 
25: Brandner S, Schroeter S, Çalışkan G, Salar S, Kobow K, Coras R, Blümcke I, Hamer H, Schwarz M, Buchfelder M, Maslarova A. Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment? Epilepsia. 2022 Jan;63(1):209-221. doi: 10.1111/epi.17107. Epub 2021 Oct 23. PMID: 34687218.
 
24: Çaliskan G#, French T, Enrile Lacalle S, Del Angel M, Steffen J, Heimesaat MM, Rita Dunay I, Stork O. Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus. Brain Behav Immun. 2021 Oct 18;99:203-217. # Corresponding Author
 
23: Madencioglu DA, Çaliskan G, Yuanxiang P, Rehberg K, Demiray YE, Kul E, Engler A, Hayani H, Bergado-Acosta JR, Kummer A, Müller I, Song I, Dityatev A, Kähne T, Kreutz MR, Stork O. Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function. iScience. 2021 Jul 19;24(8):102868.
 
22: Annamneedi A, Del Angel M, Gundelfinger ED, Stork O, Çaliskan G#. The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling. Int J Mol Sci. 2021 Jul 26;22(15):7944.
# Senior/Corresponding Author
 
21: Çaliskan G, Müller A, Albrecht A. Long-Term Impact of Early-Life Stress on Hippocampal Plasticity: Spotlight on Astrocytes. Int J Mol Sci. 2020;21(14):E4999. Published 2020 Jul 15. doi:10.3390/ijms21144999
 
20: Çaliskan G#, Raza SA, Demiray YE, Kul E, Sandhu KV, Stork O. Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse. Nutr Neurosci. 2019 Dec 9:1-12. # Corresponding Author

19: Ivens S*, Çaliskan G*, Papageorgiou I, Cesetti T, Malich A, Kann O, Heinemann U, Stork O, Albrecht A. Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Dec;67(12):2279-2293. * Equal Contribution
 
18: Çaliskan G#, Stork O. Hippocampal network oscillations at the interplay between innate anxiety and learned fear. Psychopharmacology (Berl). 2019. Jan;236(1):321-338. # Corresponding Author
 
17: Annamneedi A*, Caliskan G*, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger ED, Stork O. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Struct Funct. 2018 Sep;223(7):3423-3445. * Equal Contribution
 
16: Çaliskan G#, Stork O. Hippocampal network oscillations as mediators of behavioural metaplasticity: Insights from emotional learning. Neurobiol Learn Mem. 2018 Oct;154:37-53.
# Corresponding Author
 
15: Raza SA, Albrecht A, Çaliskan G, Müller B, Demiray YE, Ludewig S, Meis S, Faber N, Hartig R, Schraven B, Lessmann V, Schwegler H, Stork O. HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun. 2017 Aug 4;8(1):189.
 
14: Albrecht A, Müller I, Ardi Z, Çaliskan G, Gruber D, Ivens S, Segal M, Behr J, Heinemann U, Stork O, Richter-Levin G. Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience. Neurosci Biobehav Rev. 2017 Mar;74(Pt A):21-43.
 
13: Klaft ZJ, Hollnagel JO, Salar S, Caliskan G, Schulz SB, Schneider UC, Horn P, Koch A, Holtkamp M, Gabriel S, Gerevich Z, Heinemann U. Adenosine A1 receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices. Epilepsia. 2016 Apr 18.
 
12: Albrecht A, Ivens S, Papageorgiou I, Çaliskan G, Saiepour N, Brueck W, Richter-Levin G, Heinemann U, Stork O. Shifts in excitatory/ inhibitory balance by juvenile stress: A role for neuron-astrocyte interaction in the dentate gyrus. Glia.  2016 Jun;64(6):911-22.
 
11: Çaliskan G, Müller I, Semtner M, Winkelmann A, Sporbert A, Raza A, Hollnagel J, Rösler A, Heinemann U, Stork O, Meier JC. Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence. Cereb Cortex. 2016 May;26(5):2325-40.
 
10: Gruber D, Gilling K, Albrecht A, Bartsch JC, Çaliskan G, Richter-Levin G, Stork O, Heinemann U, Behr J. 5-HT receptor-mediated modulation of granule cell inhibition after stress recovers after a second exposure to stress in adulthood. Neuroscience. 2015 May 7;293:67-79.
 
9: Çaliskan G, Albrecht A, Hollnagel JO, Rösler A, Richter-Levin G, Heinemann U, Stork O. Long-term changes in the CA3 associative network of fear-conditioned mice. Stress. 2015;18(2):188-97.
 
8: Çaliskan G, Schulz SB, Gruber D, Behr J, Heinemann U, Gerevich Z. Corticosterone and corticotropin-releasing factor acutely facilitate gamma oscillations in the hippocampus in vitro. Eur J Neurosci. 2015 Jan;41(1):31-44.
 
7: Müller I, Çaliskan G, Stork O. The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology. Genes Brain Behav. 2015 Jan;14(1):37-45.
 
6: Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Jüttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC. Changes in neural network homeostasis trigger neuropsychiatric symptoms. J Clin Invest. 2014 Feb;124(2):696-711.
 
5: Caliskan G, Albrecht A. Noradrenergic interactions via autonomic nervous system: a promising target for extinction-based exposure therapy? J Neurophysiol. 2013 Dec;110(11):2507-10.
 
4: Albrecht A*, Çaliskan G*, Oitzl MS, Heinemann U, Stork O. Long-lasting increase of corticosterone after fear memory reactivation: anxiolytic effects and network activity modulation in the ventral hippocampus. Neuropsychopharmacology. 2013 Feb;38(3):386-94. * Equal Contribution
 
3: Fano S*, Çaliskan G*, Heinemann U. Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices. Eur J  Neurosci. 2012 Dec;36(12):3628-35. * Equal Contribution
 
2: Fano S, Caliskan G, Behrens CJ, Heinemann U. Histaminergic modulation of acetylcholine-induced oscillations in rat hippocampus. Neuroreport. 2011 Aug 3;22(11):520-4.
 
1: Liotta A*, Caliskan G*, ul Haq R, Hollnagel JO, Rösler A, Heinemann U, Behrens CJ. Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices. J Neurophysiol. 2011 Jan;105(1):172-87.
* Equal Contribution

NATIONAL AND INTERNATIONAL COOPERATION PARTNERS

Prof. Michael T. Heneka

c/o Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie, Bonn

Prof. Hermona Soreq

The Alexander Silberman Institute of Life Sciences
The Hebrew University of Jerusalem, Jerusalem, Israel

Dr. Katarzyna Winek

Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany

Dr. Sanja Bauer-Mikulovic

Leibniz Institute for Neurobiology, Magdeburg

Prof. Ildiko Dunay

Institut für Inflammation und Neurodegeneration, Otto-von-Guericke University Magdeburg

Prof. Eckart Gundelfinger

Leibniz Institute for Neurobiology, Magdeburg

Prof. Anne Albrecht

Institute of Anatomy, Otto-von-Guericke University Magdeburg

Dr. Anna Maslarova

Universitätsklinikum Erlangen, Neurochirurgie, Erlangen

Expertenprofil

I have been studying cellular and circuit-level changes in animal models of fear and anxiety via combining different approaches including electrophysiology, behaviour and pharmacogenetics (DREADDs). My current research focuses on identification of physiological and pathological alterations in the hippocampal activity patterns and their relation to modulation of hippocampal engrams in animal models of neuropsychiatric disorders. I am also interested in the impact of environmental factors and their interactions with immune system in mediation of affective behaviour.

Serviceangebot

In vitro / in vivo electrophysiology
Stereotaxy
Rodent Behavior
Immunohistochemistry

Forschung • Kooperationen

Projekte

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Kooperationsliste

  • Dr. med. Dr. rer. nat. Katarzyna Winek
  • Dr. rer. nat. Anil Annamneedi
  • Dr. rer. nat. Emre Kul
  • Dr. rer. nat. Syed Ahsan Raza
  • Prof. Dr. Eckart Gundelfinger
  • Prof. Dr. med. Dr. rer. nat. Anne Albrecht
  • Prof. Dr. Gal Richter-Levin, Universität Haifa
  • Prof. Dr. Oliver Stork, Institut für Biologie, OvGU Magdeburg
  • Prof. Hermona Soreq, Hebrew University, Jerusalem

Publikationen

Top-5 Publikationen

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Publikationsliste

2023
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2022
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2021
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2020
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2019
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ältere
2018
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2017
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2016
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2015
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2013
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2011
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