Ph. D. Gürsel Caliskan
Otto-von-Guericke-Universität Magdeburg
Fakultät für Naturwissenschaften
Leipzigerstr. 44
39120
Magdeburg
Tel.:+49 391 6755108
Profil • Service
Vita
from 01/2020 |
Researcher, Group Leader, Research Group “Synapto-Oscillopathies” |
06/2022-09/2022 |
Parental Leave (Elternzeit) |
EDUCATION / PREVIOUS POSITIONS
10/2014-12/2019 |
Postdoctoral Research Associate, Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany, Advisor: Prof. Dr. Oliver Stork |
04/2009-09/2014 |
PhD Student and Research Associate, Humboldt University and Free University of Berlin, Charité Medical Faculty, Germany |
11/2008-03/2009 |
Guest Student, Department of Psychology, University of Otago, Dunedin, New Zealand, Prof. Dr. David K. Bilkey; Training on in vivo tetrode recordings and data analysis |
10/2008 |
Guest Student, Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Tröndheim, Norway, Prof. Edvard Moser and Prof. May-Britt Moser; Training on in vivo tetrode recordings and data analysis |
09/2006-06/2008 |
Master Course International Graduate Program-Medical Neurosciences, Humboldt University, Charité Medical Faculty, Berlin-Germany |
09/2002-06/2006 |
Undergraduate studies of Molecular Biology and Genetics, Istanbul Technical University, Istanbul-Turkey - BSc (21.06.2006) GPA: 3.33 out of 4.00 possible |
RESEARCH FOCUS
I have been studying cellular and circuit-level changes in animal models of fear and anxiety via combining different approaches including electrophysiology, behaviour and pharmacogenetics (DREADDs). My current research focuses on identification of physiological and pathological alterations in the hippocampal activity patterns and their relation to modulation of hippocampal engrams in animal models of neuropsychiatric disorders. I am also interested in the impact of environmental factors and their interactions with immune system in mediation of affective behaviour.
GRANTS
01/2020-12/2022 |
Principal Investigator - NeuroNetwork: “A Neuronetwork for functional analysis of the engram connectome"; Subproject: "Bottom-up modulation of hippocampal engrams via sustained amygdalar activity" (Funded by the federal state of Saxony-Anhalt and the „European Regional Development Fund“ (ERDF 2014-2020); Center for Behavioral Brain Sciences, grant ID: ZS/2016/04/78113) - € 155,710 (€ 465,000 total funding) |
06/2018- |
Postdoctoral Fellowship CBBS ScienceCampus -"Elucidating the role of ventral hippocampal network oscillations in fear memory persistence" (Funded by the Leibniz Association, grant ID: SAS-2015-LIN-LWC) - € 80,000 |
AWARDS
10/2022 |
CBBS Best Paper Award 2021: “Çaliskan G, et al., Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus. Brain Behav Immun. 2021 Oct 18;99:203-217” |
11/2021 |
Selected to attend the Cajal course on Optogenetics, chemogenetics and biosensors for cellular and circuit neuroscience Bordeaux School of Neuroscience in Bordeaux, France, on 22 November - 10 December 2021 |
07/2021 |
Travel Award, The 44th Annual Meeting of the Japan Neuroscience Society 2021 in Kobe Convention Center, July 28-31, 2021 |
04/2017 |
Travel Award, IBRO-PERC, The Brain Prize and FENS Stipend, the Spring Brain Conference 2017, Learning, Memory and Synaptic Plasticity, Rungstedgaard, Denmark |
11/2016 |
Travel Award, German Neuroscience Society-Leopoldina, „Brains in vivo and in silico: from Synapses and Circuits to Brain-Inspired Technologies" in Jerusalem, Israel |
07/2016 |
FENS /IBRO Travel Award, Copenhagen, Denmark |
10/2015 |
Travel Award, FENS Featured Regional Meeting, Thessaloniki, Greece |
04/2009-06/2011 |
Doctoral PhD stipend, Graduate School Learning and Memory (GRK 1123), Humboldt University and Free University of Berlin, Charité Medical Faculty, Germany |
07/2007 |
Travel Award, Onassis Foundation Science Lecture Series, Lectures in Biology devoted to "Channels and Channelopathies", Crete, Greece |
TEACHING AND MENTORING
Graduate Neuroscience Courses:
Three Lectures, two practical courses, a writing course and a seminar series in MSc Integrative Neuroscience Program:
from 04/2022 |
Lecture on "Neuromodulation and Neuropeptides" |
from 11/2021 |
Co-supervision of a writing course for master thesis project proposal - “Neural Signalling” |
from 11/2021 |
Lecture on "Dendritic Integration" |
from 11/2018 |
Lecture on "Synaptic plasticity" |
from 10/2016 |
Co-supervision of a practical course on Genetic models |
from 04/2015 |
Lecture on "Cellular mechanisms of network oscillations in the brain" |
from 06/2015 |
Seminar Series |
from 01/2015 |
Lead supervision of a course on recording and analysis of electrophysiological data |
Mentoring:
Currently direct supervision of 1 BSc, 1 MSc, 1 PhD student and co-supervision of 3 PhD Students.
Supervision of several lab rotations (~1 month) and long-term internships (4-to-9 months) of BSc and MSc students (13 in total) and 2 MSc Theses.
ORGANIZATION OF CONFERENCES/SYMPOSIA
03/2021 |
ISYNC: International SynAGE conference on healthy ageing (Organization of scientific sessions) |
09/2019 |
MCB-Brain Plasticity International Conference (Organization committee- Postdocs in Magdeburg Science Community, funded by CBBS) |
11/2010 |
Berlin Brain Days (Invitation of Nobel Laureate Prof. Edvard Moser) |
04/2009 |
Berlin Brain Days (Invitation of Prof. Gábor Támás) |
INVITED SEMINARS AND TALKS
12/2022 |
Blitz Talk, SynAGE Retreat, Wanzleben, Germany |
10/2022 |
“CBBS Paper of the year 2021", CBBS General Assembly, Magdeburg, Germany |
09/2022 |
Invited Talk, Multi lab retreat/symposium CoSMOs 2022, Prague, Czech Republic |
05/2022 |
5th Conference on the Functional Architecture of Memory - Blitz Talk, Magdeburg, Germany |
05/2022 |
"GC-I³ Paper of the year 2021" Symposium, Magdeburg, Germany |
02/2022 |
Invited CBBS – Ring Lecture, Magdeburg, Germany |
03/2021 |
Invited Seminar Series – Mikulovic / Remy Lab - Leibniz Institute for Neurobiology, Magdeburg, Germany |
08/2020 |
Invited Lecture Series - RTG 2413 - SynAGE |
09/2019 |
Session chair and talk, MCB-Brain Plasticity International Conference, Magdeburg, Germany |
03/2019 |
Replacement talk, Proteins and Circuits in Memory, Copenhagen, Denmark |
12/2018 |
Invited Seminar, Friedrich-Alexander-University of Erlangen-Nuremberg |
10/2018 |
Invited Seminar, Junior Researcher Journal Club, Magdeburg, Germany |
05/2018 |
Invited Lecture Series – ABINEP Graduate School |
03/2017 |
37th European Winter Conference on Brain Research, Les Arcs 1800, France |
MEMBERSHIPS IN SCIENTIFIC SOCIETIES
from 01/2016 |
Federation of European Neurosciences (FENS) |
from 01/2016 |
German Neuroscience Society |
REVIEWING/EDITING ACTIVITIES
from 2022 |
Grant Reviewer, The German-Israeli Foundation for Scientific Research and Development (GIF) |
from 2022 |
Reviewer, Translational Neurodegeneration |
from 2022 |
Reviewer, Molecular Neurobiology |
from 2022 |
Reviewer, Neuropsychopharmacology |
from 2022 |
Reviewer, Journal of Neuroimmunology |
from 2021 |
Reviewer, Hippocampus |
from 2021 |
Reviewer, Neural Regeneration Research |
from 2021 |
Guest Associate Editor, Frontiers in Behavioural Neuroscience |
from 2021 |
Reviewer, Bioengineered-TAND |
from 2021 |
Reviewer, Cells-MDPI |
from 2020 |
Reviewer, Scientific Reports |
from 2020 |
Reviewer, Brain Research Bulletin |
from 2020 |
Reviewer, Psychoneuroendocrinology |
from 2020 |
Guest Associate Editor, Frontiers in Neural Circuits - Research Topic |
from 2020 |
Reviewer, International Journal of Molecular Sciences |
from 2020 |
Reviewer, Molecular and Cellular Neuroscience |
from 2019 |
Reviewer, Cerebral Cortex |
from 2019 |
Reviewer, Neuropharmacology |
from 2018 |
Reviewer, Frontiers in Molecular Neuroscience |
from 2018 |
Reviewer, Neurobiology of Learning and Memory |
from 2015 |
Reviewer, Stress- The International Journal on the Biology of Stress |
LANGUAGES
Turkish |
Native proficiency |
English |
Full professional proficiency |
German |
Limited professional proficiency (~B2) |
RELEVANT QUALIFICATIONS
From 2009 |
FELASA certificate, the Federation of European Laboratory Animal Science Associations |
From 2016 |
Security officer at the Institute of Biology, Otto-von-Guericke University Magdeburg |
From 2017 |
Deputy Head of two Animal experimentation projects (Tierversuchsvorhabens nach § 8 Abs. 1 des Tierschutzgesetzes) |
From 2020 |
Member of an appointment committee for Professorship at the Institute of Biology, Otto-von-Guericke University Magdeburg |
From 2021 |
First Aid officer at the Institute of Biology, Otto-von-Guericke University Magdeburg |
From 2021 |
Project Leader Qualification (Projektleiterkurs nach § 28 Abs. 2 der Gentechnik-Sicherheitsverordnung) |
PUBLICATIONS
Number of Papers in peer-reviewed journals: 26 (14 first or shared first authorships; 1 last/senior authorship)
(Total impact: 142.97, Citations=488, h-index=13, Based on Scopus database; Date: 04.12.2022, full publication list available via: https://www.scopus.com/authid/detail.uri?authorId=36937488100)
Preprints:
30: Çaliskan G, Demiray YE, Stork O Comparison of three common inbred mouse strains reveals substantial differences in hippocampal GABAergic interneuron populations and in vitro network oscillations, Authorea. November 17, 2022. doi: 10.22541/au.166869703.35567638/v1
29: Raza SA, Klinger K, del Ángel M, Demiray YE, Çaliskan G, Kreutz MR, Stork O (2022) Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization. bioRxiv 2022.04.26.489543; doi: 10.1101/2022.04.26.489543
28: Pollali E, Hollnagel J-O, Çaliskan G# (2022) Hippocampal gamma-band oscillopathy in a mouse model of Fragile X Syndrome. bioRxiv 2021.04.24.441239; doi: https://doi.org/10.1101/2021.04.24.441239. # Senior/Corresponding Author
Editorials:
27: Çaliskan G#, Mikulovic S# and Girardeau G# (2022) Editorial: Functional Aspects of Mesoscopic Brain Oscillations: Insights From in vivo and in vitro Studies. Front. Neural Circuits 16:960157. doi: 10.3389/fncir.2022.96015. #Corresponding Author
Published papers in peer-reviewed journals:
26: Albrecht A, Müller I, Weiglein A, Pollali E, Çaliskan G, Stork O. Choosing memory retrieval strategies: A critical role for inhibition in the dentate gyrus. Neurobiol Stress. 2022 Jul 31;20:100474. doi: 10.1016/j.ynstr.2022.100474. PMID: 35958670; PMCID: PMC9357949.
25: Brandner S, Schroeter S, Çaliskan G, Salar S, Kobow K, Coras R, Blümcke I, Hamer H, Schwarz M, Buchfelder M, Maslarova A. Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does
chronic stress contribute to memory impairment? Epilepsia. 2021 Oct 23.
24: Çaliskan G#, French T, Enrile Lacalle S, Del Angel M, Steffen J, Heimesaat MM, Rita Dunay I, Stork O. Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus. Brain Behav Immun. 2021 Oct 18;99:203-217. # Corresponding Author
23: Madencioglu DA, Çaliskan G, Yuanxiang P, Rehberg K, Demiray YE, Kul E, Engler A, Hayani H, Bergado-Acosta JR, Kummer A, Müller I, Song I, Dityatev A, Kähne T, Kreutz MR, Stork O. Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function. iScience. 2021 Jul 19;24(8):102868.
22: Annamneedi A, Del Angel M, Gundelfinger ED, Stork O, Çaliskan G#. The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling. Int J Mol Sci. 2021 Jul 26;22(15):7944.
# Senior/Corresponding Author
21: Çaliskan G, Müller A, Albrecht A. Long-Term Impact of Early-Life Stress on Hippocampal Plasticity: Spotlight on Astrocytes. Int J Mol Sci. 2020;21(14):E4999. Published 2020 Jul 15. doi:10.3390/ijms21144999
20: Çaliskan G#, Raza SA, Demiray YE, Kul E, Sandhu KV, Stork O. Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse. Nutr Neurosci. 2019 Dec 9:1-12. # Corresponding Author
19: Ivens S*, Çaliskan G*, Papageorgiou I, Cesetti T, Malich A, Kann O, Heinemann U, Stork O, Albrecht A. Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase. Glia. 2019 Dec;67(12):2279-2293. * Equal Contribution
18: Çaliskan G#, Stork O. Hippocampal network oscillations at the interplay between innate anxiety and learned fear. Psychopharmacology (Berl). 2019. Jan;236(1):321-338. # Corresponding Author
17: Annamneedi A*, Caliskan G*, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger ED, Stork O. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Struct Funct. 2018 Sep;223(7):3423-3445. * Equal Contribution
16: Çaliskan G#, Stork O. Hippocampal network oscillations as mediators of behavioural metaplasticity: Insights from emotional learning. Neurobiol Learn Mem. 2018 Oct;154:37-53.
# Corresponding Author
15: Raza SA, Albrecht A, Çaliskan G, Müller B, Demiray YE, Ludewig S, Meis S, Faber N, Hartig R, Schraven B, Lessmann V, Schwegler H, Stork O. HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun. 2017 Aug 4;8(1):189.
14: Albrecht A, Müller I, Ardi Z, Çaliskan G, Gruber D, Ivens S, Segal M, Behr J, Heinemann U, Stork O, Richter-Levin G. Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience. Neurosci Biobehav Rev. 2017 Mar;74(Pt A):21-43.
13: Klaft ZJ, Hollnagel JO, Salar S, Caliskan G, Schulz SB, Schneider UC, Horn P, Koch A, Holtkamp M, Gabriel S, Gerevich Z, Heinemann U. Adenosine A1 receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices. Epilepsia. 2016 Apr 18.
12: Albrecht A, Ivens S, Papageorgiou I, Çaliskan G, Saiepour N, Brueck W, Richter-Levin G, Heinemann U, Stork O. Shifts in excitatory/ inhibitory balance by juvenile stress: A role for neuron-astrocyte interaction in the dentate gyrus. Glia. 2016 Jun;64(6):911-22.
11: Çaliskan G, Müller I, Semtner M, Winkelmann A, Sporbert A, Raza A, Hollnagel J, Rösler A, Heinemann U, Stork O, Meier JC. Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence. Cereb Cortex. 2016 May;26(5):2325-40.
10: Gruber D, Gilling K, Albrecht A, Bartsch JC, Çaliskan G, Richter-Levin G, Stork O, Heinemann U, Behr J. 5-HT receptor-mediated modulation of granule cell inhibition after stress recovers after a second exposure to stress in adulthood. Neuroscience. 2015 May 7;293:67-79.
9: Çaliskan G, Albrecht A, Hollnagel JO, Rösler A, Richter-Levin G, Heinemann U, Stork O. Long-term changes in the CA3 associative network of fear-conditioned mice. Stress. 2015;18(2):188-97.
8: Çaliskan G, Schulz SB, Gruber D, Behr J, Heinemann U, Gerevich Z. Corticosterone and corticotropin-releasing factor acutely facilitate gamma oscillations in the hippocampus in vitro. Eur J Neurosci. 2015 Jan;41(1):31-44.
7: Müller I, Çaliskan G, Stork O. The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology. Genes Brain Behav. 2015 Jan;14(1):37-45.
6: Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Jüttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC. Changes in neural network homeostasis trigger neuropsychiatric symptoms. J Clin Invest. 2014 Feb;124(2):696-711.
5: Caliskan G, Albrecht A. Noradrenergic interactions via autonomic nervous system: a promising target for extinction-based exposure therapy? J Neurophysiol. 2013 Dec;110(11):2507-10.
4: Albrecht A*, Çaliskan G*, Oitzl MS, Heinemann U, Stork O. Long-lasting increase of corticosterone after fear memory reactivation: anxiolytic effects and network activity modulation in the ventral hippocampus. Neuropsychopharmacology. 2013 Feb;38(3):386-94. * Equal Contribution
3: Fano S*, Çaliskan G*, Heinemann U. Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices. Eur J Neurosci. 2012 Dec;36(12):3628-35. * Equal Contribution
2: Fano S, Caliskan G, Behrens CJ, Heinemann U. Histaminergic modulation of acetylcholine-induced oscillations in rat hippocampus. Neuroreport. 2011 Aug 3;22(11):520-4.
1: Liotta A*, Caliskan G*, ul Haq R, Hollnagel JO, Rösler A, Heinemann U, Behrens CJ. Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices. J Neurophysiol. 2011 Jan;105(1):172-87.
* Equal Contribution
NATIONAL AND INTERNATIONAL COOPERATION PARTNERS
Prof. Michael T. Heneka |
c/o Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie, Bonn |
Prof. Hermona Soreq |
The Alexander Silberman Institute of Life Sciences |
Dr. Katarzyna Winek |
Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany |
Dr. Sanja Bauer-Mikulovic |
Leibniz Institute for Neurobiology, Magdeburg |
Prof. Ildiko Dunay |
Institut für Inflammation und Neurodegeneration, Otto-von-Guericke University Magdeburg |
Prof. Eckart Gundelfinger |
Leibniz Institute for Neurobiology, Magdeburg |
Prof. Anne Albrecht |
Institute of Anatomy, Otto-von-Guericke University Magdeburg |
Dr. Anna Maslarova |
Universitätsklinikum Erlangen, Neurochirurgie, Erlangen |
Expertenprofil
Serviceangebot
Stereotaxy
Rodent Behavior
Forschung • Kooperationen
Projekte
Kooperationsliste
- Dr. med. Dr. rer. nat. Katarzyna Winek
- Dr. rer. nat. Anil Annamneedi
- Dr. rer. nat. Emre Kul
- Dr. rer. nat. Syed Ahsan Raza
- Prof. Dr. Eckart Gundelfinger
- Prof. Dr. med. Dr. rer. nat. Anne Albrecht
- Prof. Dr. Hermona Soreq
- Prof. Dr. Gal Richter-Levin, Universität Haifa
- Prof. Dr. Oliver Stork, Institut für Biologie, OvGU Magdeburg