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Small regulatory RNAs with a role in the virulence of <I>Xanthomonas campestris</I> pv. <I>vesicatoria</I>

Deutsche Forschungsgemeinschaft (DFG) ;
RNA regulators modulate a wide range of physiological processes. Based on data from animal pathogenic bacteria it is evident that small-noncoding RNAs (sRNAs) contribute to virulence gene expression. The majority of sRNA regulators act on translation and stability of target mRNAs through complementary base pairing. E. coli expresses some 80 sRNAs, bat there is little information about RNA regulators in bacterial plant pathogens. We study the Gram-negative plant-pathogenic bacterium Xanthomonas campestris pv. vesicatoria (Xcv), which causes disease on pepper and tomato and is a model system in molecular plant pathology. The bacteria enter the plant tissue via natural openings or wounds and multiply in the intercellular spaces. Bacterial pathogenicity and many virulence-associeted genes are induced upon contact with the plant cells. An essential pathogenicity factor of Xcv is the type III secretion system (T3SS), which translocates bacterial effector proteins directly into the cytosol of eukaryotic host cells. In this project we aim to elucidate the possible importance of sRNA-binding proteins for virulence of Xcv.


<I>Xanthomonas</I>, sRNAs, type III secretion system (T3SS)


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