CD95 Komplexe

The induction of a particular CD95 pathway is crucially dependent on the formation of the corresponding signaling platform or multiprotein complex. The induction of apoptosis via CD95 is regulated by the death-inducing signaling complex, which comprises oligomerized, CD95, the adaptor protein FADD, procaspases-8/10 and cellular FLICE inhibitory proteins (c-FLIP). The interactions between the molecules at the DISC are based on the homotypic contacts. The DD of CD95 interacts with the DD of FADD, while the death-effector domain (DED) of FADD interacts with the N-terminal tandem DEDs of procaspase-8/10 and the c-FLIP proteins.