Deutsches Zentrum für Psychische Gesundheit (DZPG) C-I-R-C Teilprojekt JE4: Immune Mechanisms in mental health

Immunologische Mechanismen der psychischen Gesundheit:

The project aims at elucidating how inflammation-triggered immune mechanisms influence mental health. Based on preliminary work and current knowledge we will focus on cognitive dysfunction and depression for which a direct link to systemic and CNS immune activation has been established. To this end, we propose to (i) characterize neuropsychiatric symptoms and perform immunophenotyping in patients with systemic inflammation and in patients with atypical depression which is known to be associated with low-grade inflammation and to (ii) unravel mechanistic events of immune-mediated brain dysfunction leading to neuropsychiatric disease.