Kurt-Mothes-Straße 3
06120
Halle (Saale)
Tel.:+49 345 5524983
Prof. Dr. Panagiotis Kastritis
Martin-Luther-Universität Halle-Wittenberg
Naturwissenschaftliche Fakultät I
Institut für Biochemie und Biotechnologie
Enzymopathies are genetic metabolic disorders due to missing or defective enzymes. Understanding enzyme structure, function, and interactions in their native cellular context is crucial. Enzymes in cells form metabolons, enhancing metabolic pathway efficiency. Grasping the molecular organization of these supercomplexes is challenging due to size and transience. Traditional structural biology methods illuminate individual enzymes but not their higher-order assembly and interfaces.My research integrates structural, biophysical, biochemical, and biocomputational approaches to unravel the molecular architecture of metabolons, aiming to elucidate atomic-level mechanisms in cellular respiration. Ultimately, it offers insights into cell mechanisms, potentially explaining how protein subunits synchronize for specific functions. Supercomplexes offer new opportunities for targeted drug design by focusing on unique protein interfaces rather than individual subunit active sites.
Profil • Service
Vita
| Stages | Periods and Details | |
Degree programme |
2002-2008 |
Biology, 2002-2008, University of Vienna (Austria) |
Doctorate |
2012 |
Chemistry, University of Utrecht (The Netherlands) |
Stages of academic/ professional |
Since 2024 |
Professor at Martin-Luther-University Halle-Wittenberg (Germany) |
Since 2023 |
ERA Chair for cryo-EM and Elected Senior Researcher, National Hellenic Research Foundation, Athens (Greece) | |
2018 - 2024 |
Junior Professor in cryo-electron microscopy, Martin-Luther-University Halle-Wittenberg (Germany) | |
Since 2018 |
Group Leader in “cryo-EM of membrane-bound protein complexes”, IWE ZIK HALOmem, Martin-Luther-University Halle-Wittenberg (Germany) | |
2013-2018 |
Postdoctoral Scientist in Structural and Molecular Biology, EMBL Heidelberg (Germany) | |
2012-2013 |
Postdoctoral Scientist in Computational Structural Biology, University of Utrecht (The Netherlands) | |
2008-2012 |
Doctoral Researcher in Computational Structural Biology, University of Utrecht (The Netherlands) |
Expertenprofil
- Molecular Biophysics
- Electron Cryo-microscopy
- Computational Structural Biology
- Biochemistry
- Integrative Structural Biology
Serviceangebot
- Electron cryo-microscopy of biomolecular complexes
- Assistance in computational structural analysis of large biomolecular complexes
Forschung • Kooperationen
Forschergruppen
Projekte
Kooperationsliste
- BSRC Alexander Flemming, Dr. Georgios Skretas
- BioTechMed-Graz, Prof. Sandro Keller
- Center for Structural Mass Spectrometry, Prof. Andrea Sinz
- Centro Nacional de Biotecnologia (CNB-CSIC), Prof. José María Carazo
- European Molecular Biology Laboratory (Hamburg), Dr. Jan Kosinski
- German Centre for Integrative Biodiversity Research (iDiv), Prof. Dr. Marcel Quint
- Imperial College, Dr. Thodoris Karamanos
- Izmir Biomedicine and Genome Center, Ass. Prof. Dr. Ezgi Karaca
- Leibniz Institut für Pflanzenbiochemie, Prof. Dr. Alain Tissier
- Leibniz Institute of Plant Genetics and Crop Plant Research
- Leipzig University Medical School, Dr. Georg Künze
- Max Planck Institute for Dynamics of Complex Technical Systems, Prof. Dr. Kai Sundmacher
- Max Planck Institute of Colloids and Interfaces, Dr. Rumiana Dimova
- National Cancer Institute (NCI), NIH, Dr. Francis O' Reilly
- National Hallenic Research Foundation, Athens, Dr. Christos Chochos
- National Hellenic Research Foundation, Athens, Dr. Christos Chochos
- National and Kapodistrian University of Athens, Prof. Dr. Costas Vorgias
- Palacky University, Dr. Roman Kouřil
- RGCC International GmbH, Zug, Dr. Ioannis Papasotiriou
- TU Braunschweig, Prof. Dr. Tobias Kruse
- Technische Universität Berlin, Prof. Dr. Juri Rappsilber
- University of Geneva, Prof. Dr. Robbie Loewith
- University of Graz, Prof. Dr. Sandro Keller
- University of L'Aquila, Dr. Claudio Iacobucci
- University of Manchester, Prof. Dr. Christos Pliotas
- University of Patras, Prof. Dr. Georgios Spyroulias
- University of Regensburg, Prof. Dr. Christine Ziegler
- University of Tennessee, Prof. Dr. Barry Bruce
- University of Vienna, Prof. Dr. Lea Ann Dailey
- Utrecht University, Prof. Dr. Alexandre Bonvin