« Projekte
Aktivierung der membranständigen Guanylatzyklase ROS-GC1 durch Ca(2+)-bindende Proteine
Finanzierung:
Deutsche Forschungsgemeinschaft (DFG) ;
Cyclic GMP is the second messenger in vertebrate phototransduction. Two isoforms of membrane-bound guanylate cyclase, ROS-GC1 and 2, have been found in photoreceptor outer segments and are activated by low ]free. Ca2+ -sensitivity is mediated by the lipid-modified activator proteins GCAP-1 through -3. In other tissues, ROS-GC1 is stimulated by high ]free via S100b and the lipidated Ca2+ sensor protein neurocalcin , respectively. Detailed structural information on the membrane-bound complexes of ROS-GC1 with its activators is currently not available. The aim of this new project is to reveal how the various regulatory Ca2+-binding proteins interact with the guanylate cyclase in its membrane environment, and how differential regulation is achieved.

Schlagworte

Neurocalcin delta, ROS-GC1
Kontakt
Dr. Christian Lange

Dr. Christian Lange

Martin-Luther-Universität Halle-Wittenberg

Naturwissenschaftliche Fakultät I

Institut für Biochemie und Biotechnologie

Kurt-Mothes-Str. 3

06120

Halle (Saale)

Tel.+49 345 5524948

Fax:+49 345 5527013

christian.lange(at)biochemtech.uni-halle.de

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