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Preoperative chemoradiotherapy and postoperative chemotherapy with capecitabine and oxaliplatin vs. capecitabine alone in locally advanced rectal cancer (PETACC 6)
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Fördergeber - Sonstige;
This is an open-label, randomized, multi-center, 2-arm phase III trial.Criteria for evaluation Efficacy (Disease-free survival (primary endpoint)¨, Overall survival, Loco-regional failure, Distant failure, Pathological down-staging (ypT0-2N0) rate, Pathological complete remission (ypT0N0) rate, Tumor regression grade,  Histopathological R0 resection rate, Sphincter preservation rate) Safety (Perioperative complication rate, Toxicity)

Schlagworte

Capecitabine, Oxaliplatin, Rektum-Karzinom, Strahlenchemotherapie
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