Predicting Recurrent Hemorrhage in Lobar Intracerebral Hemorrhage Using Blood-Based Biomarkers: A Prospective Study

Spontaneous lobar intracerebral hemorrhage (ICH) is commonly caused by cerebral amyloid angiopathy (CAA) or arteriolosclerosis, with CAA conferring a particularly high risk of recurrent hemorrhage and poor long-term outcome. As MRI-based CAA diagnosis is often limited by contraindications or availability, accessible blood-based biomarkers may offer a valuable alternative for early risk stratification. This prospective cohort study evaluates blood serum phosphorylated tau 217 (p-tau217), measured using a Lumipulse immunoassay, for its ability to predict recurrent hemorrhage and other vascular outcomes, with the aim of defining clinically relevant cutoff values and assessing its prognostic accuracy in patients with lobar ICH.