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An Open-label, single-arm, Phase II study to evaluate the efficacy and the feasibility of bevacizumab (Avastin®) based on a FOLFOXIRI regimen until progression in patients with previously untreated metastatic colorectal carcinoma (OPAL-Study)
Projektleiter:
Finanzierung:
Fördergeber - Sonstige;
Indikation: Histologically confirmed metastatic colorectal carcinoma (CRC) according to RECIST criteria with at least one primarily non-resectable metastasis to be treated with 1st line chemotherapy. Primary objective: Evaluation of progression-free survival (PFS) under a therapy with bevacizumab based on a FOLFOXIRI regimen in patients with previously untreated metastatic colo­rectal carcinoma. Secondary objectives: Further evaluation of the efficacy of a therapy with bevacizumab based on a FOLFOXIRI regimen.Determination of the feasibility and safety of a the­ra­py with bevacizumab based on a FOLFOXIRI regimen.

Schlagworte

Bevacizumab, Chemotherapie, FOLFOXIRI, Kolorektales Karzinom, palliativ
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