Analysis of vascular changes in ageing and neurodegeneration

In this work we develop MR-based segmentation techniques and analyse white matter hyperintensities (WMH) and ePVS in the DZNE DELCODE cohort. We focus on the analysis of those features in relation to age, vascular risk factors such as hyptertension, CSF-biomarkers and their cognitive consequnces. We specifically validate findings using clinically rated MR-scans.