present Postdoctoral fellow at the Institute of Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg, Germany. Boolean and kinetic network models of T cell activation.
- 05/2007 System administrator at the Center for Scientific Computing of the Goethe-University of Frankfurt am Main, Germany.
- 05/2007 PhD student at the Frankfurt Institute for Advanced Sciences, Frankfurt am Main, Germany. Receiver of a studentship of the Frankfurt International Graduate School for Sciences. Continuing PhD thesis on Spatio-Temporal Dynamics of Primary Lymphoid
- 12/2004 Guest Scientist at the Interdisciplinary Center for Bioinformatics at the University of Leipzig, Germany. Mechanistic simulation of cell migration based upon parallel kinetic Delaunay triangulations.
- 06/2004 PhD student at the Institute for Theoretical Physics at the Technical University Dresden, Germany. Thesis about Spatio-Temporal Dynamics of Primary Lymphoid Follicles During Organogenesis
- 09/2003 Guest Scientist at the Center for Information Services and High Performance Computing at the Technical University Dresden, Germany. Design and Implementation of parallel algorithms for dynamic and kinetic Delaunay triangulations.
- 05/2007 PhD in Biology, Goethe-University Frankfurt am Main, Germany. Thesis on Spatio-Temporal Dynamics of Primary Lymphoid Follicles During Organogenesis and Lymphneogenesis.
- 06/2004 PhD student at the Institute for Theoretical Physics at the Technical University Dresden, Germany. Thesis about Spatio-Temporal Dynamics of Primary Lymphoid Follicles During Organogenesis and Lymphneogenesis.
- 11/2002 Study of physics at the Technical University Dresden, Germany. Diploma thesis about Dynamische Strukturbildung in Keimzentren (Dynamical Pattern Formation in Germinal Centres).
- I used various methods to simulate the morphodynamics and pattern formation processes of multi-cellular tissue. In particular I developed and implemented the Delaunay-Object-Dynamics method for parallel computer architectures. This allows the lattice-free description of quasi-spherical particles using Newtonian physics. I applied this method to simulate the ontogenesis of secondary lymphoid tissue like the splenic white pulp and lymph nodes.
- Recently I focus on the construction and analysis of signaling networks. I mostly use rule-based network construction and concentrate on the effects of the network structure and underlying assumption to build up a signaling network. The application is mainly signaling of the T-cell receptor including MAP kinase signaling. In particular I'm interested in the changes of the network structures imposed by adaptor an scaffolding proteins.
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