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NIH Blueprint for Neuroscience Research: Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)
bis 01.02.2018
Fördergeber - Sonstige
The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders.
The goal of this FOA is to transform our understanding of how dynamic interactions among multiple cell types involved in neuroimmune interactions (e.g., neurons, glia cells, neurovascular units, or other neuroimmune components) mediate the transition from normal central nervous system (CNS) function to disorder conditions. Previous findings have markedly advanced our knowledge of neuroimmune interactions during normal brain function, neurodevelopment, and in the context of established diseases. However, there is a lack of understanding of how multiple neuroimmune components mediate transitions from normal brain function to the early stages of CNS disorders, how changes in immune signaling are integrated into neuronal networks, and how disease progression is orchestrated by multiple neuroimmune components. With this FOA, we encourage projects that combine diverse expertise and use innovative approaches to address these questions at the molecular, cellular, and circuitry levels. The outcomes of this research will provide an integrated view of the dynamic changes among multiple neuroimmune components and how they contribute to the onset and progression of CNS disorders.
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